The chemotherapeutic monoclonal antibodies and protein kinase inhibitors are considered targeted forms of therapy. How do these two classes of chemotherapeutic agents specifically target cancer? In your answer describe the mechanism of action of Trastuzumab (Herceptin) and Imatinib (Gleevac), two targeted chemotherapeutic agents representing each class. Contrast the targeted mechanisms of action of these drugs to the cytotoxic chemotherapeutic agents.
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