What morphologic alterations are seen in this blood smear field? (Please comment on the white blood cells and on the red blood cells seen in the picture.)(6 Marks)
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Get Help Now!What is the most likely diagnosis given the information given above?(1 Mark)
How do the ‘further laboratory studies’ aid with determining the diagnosis? (Please comment briefly on each test).(4 Marks)
Immunophenotyping was not performed. How could immunophenotyping have helped with the diagnosis? Name two CD markers that are likely expressed on the pictured WBC.Document Preview:
MLS202 – Haematology 2 Semester 2 – 2018 Written Assignment Due Date: Sunday 11th September 2018 23:59 hours Total marks: 15 marks Weighting: 15% Notes: Minimum 12 point font and 2.5 cm margins Please include a header containing your name, student number and unit code. Please ensure the pages of your assignment are numbered consecutively. Reference work appropriately using APA or Harvard referencing style. (For more information on referencing and plagiarism please visit HYPERLINK “http://libguides.cdu.edu.au/cdureferencing” http://libguides.cdu.edu.au/cdureferencing ) Expected length: 700 words (excluding references). Max word limit: 1000 words. Please include a word count at the end of your assignment. 5% penalty applies if the maximum word length is exceeded. Case study: History: 15 year old male. Flu-like symptoms with a severe sore throat for two weeks prior to admission. Physical Exam: Cervical and axillary adenopathy. No other organomegaly. CBC (with microscopic differential): RBC 3.15 x 1012/L (4.5-5.3 × 1012/L) HGB 9.9 g/Dl (13-16 g/dL) HCT 28.5 % (36-51 %) MCV 90.5 fL (79-98 fL) MCH 31.4 pg (25-35 pg) MCHC 34.7 g/dL (32-36 g/dL) RDW 15.2 % (11.5 – 14.0 %) WBC 42.6 x 109/L (4.5-13.0 x 109/L) Lym 12 % (25-45 %) abnormal cells 88 % (0 %) (see Picture) PLT 22 x 109/L (150-450 x 109/L) Further Laboratory Studies: Bone marrow biopsy: Aspirate: The differential showed 100% cells similar to those seen in the blood. Sections: Markedly hypercellular. Cytochemistry: Myeloperoxidase negative Sudan black B negative Non-specific esterase positive Immunophenotyping: Not done. Chemistry: Serum lysozyme 162 mg/L (RI 4-13) Please answer the following questions: What morphologic alterations are seen in this blood smear…
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