Select a disorder from below.
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Get Help Now!Explain the risk factors, pathology, manifestations, and possible complications for the disorder.
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Gouty Arthritis– Acute gouty arthritis includes recurring attacks of severe articular and periarticular inflammation; tophi or the accumulation of crystalline deposits in articular surfaces, bones, soft tissue, and cartilage.Risk factors– Primary gout may be a consequence of enzyme defects that result in an overproduction of uric acid; inadequate elimination of uric acid by the kidney or a combination of the two; however, in most cases, the reason is unknown. In secondary gout, the hyperuricemia may be caused by the increased breakdown of nucleic acids, or may be a result of kidney disease. Pathology– An attack of gout occurs when monosodium urate crystals precipitate in the joint and initiate an inflammatory response. With prolonged hyperuricemia, crystals and microtophi (small, hard nodules with irregular surfaces that contain crystalline deposits of monosodium urate) accumulate in the synovial lining cells and in the joint cartilage
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