1. After starting a continous IV infusion of a drug whole half-life (t1/2) is 2 hours, what percentage of the Css will be achieved in 6.6 hours?

1. After starting a continous IV infusion of a drug whole half-life (t1/2) is 2 hours, what percentage of the Css will be achieved in 6.6 hours?

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2. If a drug has t1/2 of 24 hours and a Vd of 40 Liters, what would the total body clearance be?

3. To achieve a loading dose of a drug where the Vd is 35L, the CL is 70 ml per minute and the desired (target) plasma concentration is 3.5mg per liter, what amount of drug should be administered initially?

4. A patient with a headache takes 500mg of a drug with t1/2 of 8 hours. With this dose the patient experiences relief of pain for 6 hours. If he doubles the dose, how many hours would the pain be relieved?

5. A new drug is ordered to a patient with a severe infection. The Cl of the drug is 50ml per minute, the Vd is 20 liters. What dose should be administered every 8 hours in order to achieve a Css of 20 mg per liter?