You are designing a randomized clinical trial of a new anti-hypertensive medication. The goal is to lower the incidence of stroke, but a surrogate endpoint will be used instead of stroke as the primary endpoint of the trial.
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(1) Give an example of a surrogate endpoint that makes sense for the context of this clinical trial.
(2) In the context of this trial, give a rationale for why an investigator might decide to use a surrogate endpoint.
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