A drug is 40% bioavailable by the oral route and 58% bioavailable by the transdermal route.

A drug is 40% bioavailable by the oral route and 58% bioavailable by the transdermal route. If a patient is taking a 2.5-mg oral dose twice a day and is switched to the counterpart 2% ointment, how many milligrams of the ointment should be administered to provide the daily equivalent dose of the drug?

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Expert Answer

Method 1: Oral drug dose = 2.5mg/day = 5mg/day Bioavailability for oral route = 40% = 5×40/100 = 2mg (Daily quivalent dose of the drug) Ointment form 2% = 2g/100g = 0.0…

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